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DuPont Liveo Healthcare Debuts Silicone Elastomer for Topical Applications

The company has developed four new low-cyclosiloxane silicone topical excipient blends.

Du Pont Liveo
DuPont

DuPont  today announced the introduction of new low-cyclosiloxane silicone elastomer blends and silicone resin blends in response to growing consumer desires for products that address a range of troubling skin conditions.

DuPont Liveo has developed four new low-cyclosiloxane silicone topical excipient blends. These products are designed to help customers meet the substance of very high concern (SVHC) threshold for concerned cyclosiloxanes – below 0.1% – proposed by REACH regulation (EC) No. 1907/2006. 

The new DuPont Liveo silicone elastomer blends are:

  • Liveo TE-9320 Silicone Elastomer Blend – a blend of silicone elastomer network swollen in a Dimethicone volatile carrier (ref. INCI names Dimethicone and Dimethicone Crosspolymer) – is a non-occlusive rheology modifier with a skin feel that is characterized by smoothness with a light, silky, non-greasy feel. It contains less than 0.1% D4, D5 and D6.
  • Liveo TE-9330 Silicone Elastomer Blend – a blend of silicone elastomer network swollen in a Dimethicone non-volatile carrier (ref. INCI names Dimethicone and Dimethicone Crosspolymer) – is a non-occlusive thickening agent for anhydrous and water-in-oil emulsions. It delivers a smooth, silky feel and contains less than 0.1% D4, D5 and D6.

Potential uses for silicone elastomer blends include topical drug delivery formulations for prescription and over-the-counter products that may improve patient compliance due to their unique sensory feel, including creams for conditions such as atopic dermatitis, psoriasis, and scar and pain management, as well as creams and gels that offer a mattifying effect for acne applications. Silicone elastomer blend technologies also are known for their effectiveness in support of drug release or drug permeation in topical semi-solid formulations thereby providing options to formulators.

The new DuPont Liveo silicone resin blends are:

  • Liveo TE-9720 Resin Blend – a blend of silicone resin solubilized in a 100 cSt Dimethicone non-volatile carrier (ref. INCI names Dimethicone and Trimethylsiloxysilicate) – exhibits film-forming behavior and delivers a long-lasting film that is resistant to water wash-off.
  • In development: Liveo TE-9721 Resin Blend – a blend of silicone resin solubilized in a Caprylyl Methicone volatile carrier (ref. INCI names Caprylyl Methicone and Trimethylsiloxysilicate) – exhibits film-forming behavior and delivers a long-lasting film that is resistant to water wash-off. Additionally, it offers good compatibility with a wide range of formulation ingredients.

Liveo silicone resin blends can be incorporated easily into many product forms, including creams for skin barrier applications, sprays that offer ease of application and protect the skin, and gels for novel product forms in challenging skin conditions. Target indications include skin barriers and protective films for ostomy care; liquid bandages, skin barriers and scar management for wound care; UV protection and sunscreens for skin care; and drug delivery therapy for acne, actinic keratosis, antifungal and pain management in dermal care.

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