Medtronic's MiniMedâ„¢ 780G System Exceeds Diabetes Management Targets in Real-World Study

New data sought to evaluate the system's ability to help users achieve Time in Tight Range goals, a new and emerging supplementary metric being discussed amongst experts.

Time in Range is the percentage of time a person with diabetes spends between 70-180 mg/dL (3.9–10.0 mmol/L). Time in Tight Range is a new and emerging metric defined as the percentage of time a person with diabetes spends in the tighter glucose range of 70-140 mg/dL (3.9-7.8 mmol/L), which lowers the upper threshold to more closely mirror the blood sugar levels of someone without diabetes (also referred to as euglycemia). The MiniMed™ 780G system users (n=13,461) achieved a TITR of greater than 56% with the use of recommended optimal settings (100 mg/dL set target with an active insulin time of 2 hours).
Time in Range is the percentage of time a person with diabetes spends between 70-180 mg/dL (3.9–10.0 mmol/L). Time in Tight Range is a new and emerging metric defined as the percentage of time a person with diabetes spends in the tighter glucose range of 70-140 mg/dL (3.9-7.8 mmol/L), which lowers the upper threshold to more closely mirror the blood sugar levels of someone without diabetes (also referred to as euglycemia). The MiniMed™ 780G system users (n=13,461) achieved a TITR of greater than 56% with the use of recommended optimal settings (100 mg/dL set target with an active insulin time of 2 hours).
Medtronic

On Saturday, Medtronic shared a set of new clinical and real-world evidence on the MiniMedâ„¢ 780G system from around the world including the largest set of data from early users in the United States. The data was presented at the 17th International Conference on Advanced Technologies and Treatments for Diabetes (ATTD) in Florence, Italy.

The results build on the three-year data published in Diabetes Technology & Therapeutics showing over 100,000 real-world users achieving a Time in Range (TIR) of 78% with the use of recommended optimal settings, outperforming international targets of 70% TIR.

New data sought to evaluate the MiniMedâ„¢ 780G system's ability to help users achieve Time in Tight Range (TITR) goals, a new and emerging supplementary metric being discussed amongst experts, which more closely mirrors the glucose levels of individuals without diabetes. Also referred to as normoglycemia or euglycemia, it is defined as the percentage of time a person spends in the glucose range of 70-140 mg/dL.

TITR lowers the upper threshold of Time in Range from 180 mg/dL to 140 mg/dL. Results showed users (n=13,461) achieved a TITR of greater than 56% with the use of recommended optimal settings (100 mg/dL set target with an active insulin time of 2 hours). This data adds to a growing body of evidence that a TITR goal of 50% or greater is a reasonably achievable goal with the right therapeutic option.

"Since the landmark DCCT study, numerous retrospective studies have demonstrated the association between increased Time in Range and a reduction of diabetic complications.1-12 There's no doubt elevated glucose is harmful and the average blood sugars of those living with type 1 diabetes are higher than we should accept as a clinical community," said Robert Vigersky, MD, Chief Medical Officer, Medtronic Diabetes. "The preponderance of data across randomized controlled trials and real-world studies show that the MiniMedâ„¢ 780G system is maximizing Time in Range far surpassing international targets and is taking it a step beyond by getting people closer to euglycemia.13,14 In the absence of a cure, our goal is to relentlessly innovate therapies to help people maximize their health without adding burden, which our newest AID system has proven to do."

In an oral presentation, Dr. James Thrasher, MD, Founder, Arkansas Diabetes and Endocrinology Center, shared data on early real-world users with type 1 diabetes of the MiniMedâ„¢ 780G system in the U.S. (n=7,499). Results showed users achieved over 80% TIR when employing the recommended optimal settings, exceeding international glycemic targets (ADA guidelines recommend 70% time in range between 70-180 mg/dL), with closed loop exits occurring less than once per week on average. The enhancements introduced in this latest system have resulted in high satisfaction and improved quality of life benefits.15,16 Indeed, the latest dQ&A(opens new window) U.S. Pump Patient Survey (n=1,997), found that among pump users, the MiniMedâ„¢ 780G system scored first in overall pump satisfaction.*,17 The survey also showed that among people with type 1 diabetes using CGM, the Guardianâ„¢ 4 sensor mirrored competitor sensors in overall satisfaction.*,18

"The results demonstrate that when the MiniMedâ„¢ 780G system is optimized with recommended optimal settings, it helps people with diabetes far exceed the ADA recommended goal of 70% Time in Range,*" said Dr. Thrasher. "The advent of AID systems has been nothing short of transformative in the practice of endocrinology and is really pushing all of us to introduce its protective benefits on overall health as early and often as possible. This data reinforces that the determinant of choice for AID systems should be first and foremost the power of the algorithm."

The development of continuous glucose monitoring enabled the development of Time in Range (TIR), a metric used today to determine whether an individual with type 1 diabetes is meeting blood sugar management goals. Since 2019, the goal of diabetes management has been to maintain the highest TIR for as long as possible while also minimizing hypoglycemia. The introduction of automated insulin delivery (AID) systems has transformed diabetes care by enabling a wider range of individuals to safely achieve blood-sugar goals with less burden and effort. AID systems are helping people achieve more ambitious goals with glucose management, prompting the emergence of a new supplementary metric that mirrors blood sugar levels of individuals without diabetes (normoglycemia or euglycemia). The MiniMedâ„¢ 780G system is demonstrating that a Time in Tight Range above 50 percent is achievable and serves as a powerful tool for those seeking more time in euglycemia. 

*Adults, T1 and parents of children with T1 diabetes < 18 years were surveyed; Individual results may vary.

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  2. Beck RW, Bergenstal RM, Riddlesworth TD, et al. Validation of time in range as an outcome measure for diabetes clinical trials. Diabetes Care 2019;42(3):400–405
  3. Lu J, Ma X, Zhou J, et al. Association of time in range, as assessed by continuous glucose monitoring, with diabetic retinopathy in type 2 diabetes. Diabetes Care 2018;41(11):2370–2376
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  9. Mayeda L, Katz R, Ahmad I, et al. Glucose time in range and peripheral neuropathy in type 2 diabetes mellitus and chronic kidney disease. BMJ Open diabetes Res Care 2020;8(1):e000991
  10. El Malahi A, Van Elsen M, Charleer S, et al. Relationship between time in range, glycemic variability, HbA1c, and complications in adults with type 1 diabetes mellitus. J Clin Endocrinol Metab 2022;107(2):e570–e581
  11. Beck RW. The association of time in range and diabetic complications: The evidence is strong. Diabetes Technol Ther 2023;25(6):375–377
  12. Zhu DD, Wu X, Cheng XX, et al. Time in range as a useful marker for evaluating retinal functional changes in diabetic retinopathy patients. Int J Ophthalmol 2023;16(6):915–920
  13. CGM & Time in Range. American Diabetes Association. Available at: https://diabetes.org/tools-support/devices-technology/cgm-time-in-range. Accessed June 19, 2023.
  14. American Diabetes Association (2019). Standards of medical care in diabetes—2019. Diabetes Care, 42(Suppl 1): S61-S70.
  15. MiniMedâ„¢ 780G system SSED
  16. Medtronic data on file: MiniMed™780G users survey conducted in April – May 202in UK, Sweden, Italy, Netherlands and Belgium. N 789
  17. dQ&A US Diabetes Patient Panel Report; Customer Overall Satisfaction, n=146; Q4 2023: P.52 (November 2023)
  18. dQ&A US Diabetes Patient Panel Report; Customer Overall Satisfaction, n=207; Q4 2023: P.85 (November 2023)

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