Vanderbilt Completes Evaluation of Four-Dimensional Lung Imaging Software

The investigators hypothesize the XV Technology, when applied to standard fluoroscopic images, is more sensitive for the diagnosis of constrictive bronchiolitis than PFTs, chest X-rays and CT scans in veterans.

4 D Medical Xv Scans

4DMedical announced successful completion of a study by Vanderbilt University Medical Center of post-deployment veterans referred by the Nashville VA. Undetectable with CT scanning and PFT testing, the pilot study demonstrated that XV LVAS analysis software successfully and non-invasively detected constrictive bronchiolitis in military veterans.

Assistant Professor Bradley W. Richmond, M.D. Ph.D., Division of Allergy, Pulmonary, and Critical Care Medicine is the principal investigator. Published results are forthcoming.

"We see many Iraq and Afghanistan veterans who have lung biopsies showing significant damage, but traditional non-invasive testing appears normal," says Dr. Richmond. "We are hopeful that 4DMedical's technology can help us diagnose lung disease in these veterans without the need for a surgical lung biopsy. If our efforts are successful, we expect this technology can also be used to detect other lung diseases earlier than traditional testing so that patients can get started on treatment sooner."

Post Deployment Respiratory Syndrome (PDRS) is the term used to describe symptoms in U.S. military personnel and veterans who were exposed to toxins, primarily burn pits, during their deployments. Constrictive bronchiolitis is an uncommon lung disease that has been diagnosed in veterans of conflicts in Iraq and Afghanistan. Although these veterans have findings of constrictive bronchiolitis on lung biopsies, non-invasive tests such as PFTs, chest X-rays and CT scans are often normal. XV LVAS is an imaging analysis algorithm which utilizes standard fluoroscopy to quantify ventilation with sufficient fidelity to identify regional differences.

On 10 August 2022, President Joe Biden signed into law a broad expansion of healthcare benefits for millions of veterans exposed to toxic burn pits. The estimated 3.5 million veterans exposed to harmful toxins while deployed on operations since 2001 will now benefit from an additional $280bn healthcare commitment over ten years. Importantly, the new law also relieves veterans from the burden of proof that an illness is associated with exposure to toxic substances, with CB listed as a presumptive condition. Included in this legislation is the requirement of the VHA to provide toxic exposure screening to each of the 9 million veterans enrolled in VHA.

The investigators hypothesize the XV Technology, when applied to standard fluoroscopic images, is more sensitive for the diagnosis of constrictive bronchiolitis than PFTs, chest X-rays and CT scans in veterans. Specific metrics that were evaluated with the 4DMedical software include measures of ventilation heterogeneity that demonstrate shift in the proportion of ventilation to various regions within the lungs. Endpoints were compared during tidal breathing and a full exhalation to residual volume from total lung capacity.

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