FDA OKs Next-Generation Donor Lung Preservation System

Most donor lungs are transported via aircraft, where ambient pressure changes may expose lungs to reach elevated pressure.

Lun Gguard In Action
Paragonix Technologies

Paragonix Technologies, an organ transplant company, received FDA clearance for its next-generation donor lung preservation system, BAROguard.

The BAROguard System combines Paragonix’s existing hypothermic preservation technology with automated continuous and active airway pressure control, ensuring that an optimal temperature range and a clinically recommended inflation pressure range for donor lungs are maintained throughout the journey from donor to recipient patient. This novel combination of advanced technologies further reinforces the company's ongoing commitment to improve and redefine the standard of care within transplant medicine.

Under current clinical practice, donor lungs are preserved and transported in an inflated state from donor to recipient site. However, current organ recovery techniques may not reliably maintain and control lung inflation pressures within the clinically recommended range of 12-15 cmH2O. Notably, most donor lungs are transported via aircraft, where ambient pressure changes may expose lungs to reach elevated pressure, which has been demonstrated in respiratory management studies to increase the risk of pulmonary barotrauma.

“The BAROguard Donor Lung Preservation System was designed to address these critical issues with an automated and easy to use active pressure management system,” said Dr. Lisa Anderson, CEO and President of Paragonix.

“Manually inflating donor lungs can be a highly variable process during lung donation. There is the belief that maintaining a consistent donor lung airway pressure can be useful for optimizing static preservation, especially when recovering organs over extended times or distances” said Dr. Jack Haney, Surgical Director, Lung Transplant Program from Duke Medical Center. “BAROguard offers the potential for significant advancement of lung preservation that we will be studying via the GUARDIAN registry.”

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