Carthera Secures Additional Funding for Ultrasound Glioblastoma Treatment

The device emits ultrasound to temporarily increase the permeability of the blood vessels in the brain.

Sono Cloud9 Implanted Carthera
Carthera

Carthera, a spin-off from Sorbonne University founded by Pr. Alexandre Carpentier and developer of SonoCloud, an ultrasound-based medical device to treat a wide range of brain disorders, announced an additional €4.5 million in funding to complement its Series B financing round, bringing the total raised to €42 million ($45 million).

The company welcomes its first US-based VC, Unorthodox Ventures, along with existing shareholders Supernova Invest, Saint-Genys and Bouscas Med.

The funding will support Carthera in launching its first registrational trial using its SonoCloud technology in the treatment of recurrent glioblastoma (rGBM). The study will be an international, multi-center, two-arm clinical trial randomized with a 1:1 ratio. The open-label, comparative pivotal trial will evaluate overall survival in patients undergoing carboplatin chemotherapy and treated with the SonoCloud-9 system to open the Blood Brain Barrier (BBB). This will be compared to the standard of care (lomustine and temozolomide) in patients with first recurrence of GBM.

The device emits ultrasound to temporarily increase the permeability of the blood vessels in the brain to improve the delivery of therapeutic molecules.

“Carthera's technology addresses a real problem, and we're pleased to support the company's work and this pivotal trial," said Carey Smith, Founding Contrarian at Unorthodox Ventures.

“Carthera continues to show positive results in the treatment of recurrent glioblastoma with its SonoCloud device; we are therefore pleased to reinforce our support for the company through this financing round,” said Celia Hart, General Partner at Supernova Invest. “We are confident that the expertise and clinical development experience of its management team will help the company to realize its ambitious plan.”

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